See clinical manifestations evaluation and management of neonatal thrombocytopenia section on platelet transfusion platelet collection there are two ways that platelets can be collected by isolation from a unit of donated blood or by apheresis from a donor in the blood bank. Laboratory evaluation of platelets a quantitation 1 estimates from peripheral blood film counting area rbc barely touching 140000 150000 to 400000 440000 plt cumm. A multi laboratory evaluation of in vitro platelet assays the tests for extent of shape change and response to hypotonic shock biomedical excellence for safer transfusion working party of the international society of blood transfusion. Platelet count is the main laboratory measurement used to guide platelet transfusion however it provides no qualitative information about platelet hemostatic function the clinical utility of in vitro platelet hemostasis testing particularly at the point of care remains a key area of exploration. Platelet transfusion refractoriness is a condition characterized by the lack of expected platelet count increment after a platelet transfusion 1 as many as 70 of patients receiving multiple platelet transfusions for thrombocytopenia will exhibit some degree of refractoriness 123 this condition is most common in patients treated for
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